Zika Preparedness Latin American Network

Supported by the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 734584

Work Package 1 Leader: Dr. Elizabeth Brickley

ZikaPLAN (Zika Preparedness Latin American Network) brings together 25 leading research and public health organizations in Latin America, North America, Africa, Asia, and Europe, taking a comprehensive approach to tackle the Zika threat.

Estimating the public health burden of arbovirus-related complications in Brazil: A population-based big data project

Supported by the British Council Newton Fund (527418645)

Co-PIs: Dr. Elizabeth Brickley (LSHTM), Prof. Mauricio Barreto (CIDACS/Fiocruz), & Prof. André Portela (FGV/EESP)

Arthropod-borne viruses (arboviruses), including Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and Chikungunya (CHIKV), are climate-sensitive, neglected tropical diseases that threaten health, economic development, and social welfare in Brazil. In recent decades, global DENV incidence increased 30-fold, ZIKV-related microcephaly triggered a Public Health Emergency of International Concern, YFV was declared a WHO global threat, and CHIKV emerged in the Americas. Using “Big Data” routinely collected on more than 100 million individuals in Brazil from 2012 to 2018, this study is quantifying the burden of arbovirus infections on hospitalizations and deaths, investigating the determinants of infection and complications, and the impact of social protection policies. This project links LSHTM, CIDACS-Fiocruz, and FGV and brings together international expertise in big data, epidemiology, and economics in order to address critical knowledge gaps vital to reducing the impact of arboviruses in Brazil.

Publications on Zika virus

Carvalho MDCG, Ximenes RAA, Andrade-Valença LPA, Montarroyos UR, Diniz GTN, Rodrigues LC, Brickley EB, Eickmann SH, de Araujo TVB, Martelli CMT, da Silva PFS, Miranda-Filho DB; Microcephaly Epidemic Research Group (MERG).. Longitudinal evolution of electroencephalogram (EEG): Findings over five years of follow-up in children with Zika-related microcephaly from the Microcephaly Epidemic Research Group Pediatric Cohort (2015-2020). Seizure. 2023 Aug;110:28-41. doi: 10.1016/j.seizure.2023.05.019. Epub 2023 May 29. PMID: 37302158.

Rosado LEP, Martelli CMT, Brickley EB, Gomes MBF, de Toledo Lima T, da Costa PSS, de Ávila MP, Viggiano MB, do Amaral WN, de Rezende Feres VC, Fiaccadori FS, de Sene Amancio Zara AL, Ferreira-Lopes A, Turchi MD. Risk of adverse pregnancy and infant outcomes associated with prenatal Zika virus infection: a post- epidemic cohort in Central-West Brazil. Sci Rep. 2023 May 5;13(1):7335. doi: 10.1038/s41598-023-33334-5. PMID: 37147405; PMCID: PMC10161159.

Costa MDCN, Cardim LL, Moore CA, de Jesus EDS, Carvalho-Sauer R, Barreto ML, Rodrigues LC, Smeeth L, Schuler-Faccini L, Brickley EB, Oliveira WK, Carmo EH, Pescarini JM, Andrade RFS, Rodrigues MMS, Veiga RV, Costa LC, França GVA, Teixeira MG, Paixão ES. Causes of death in children with congenital Zika syndrome in Brazil, 2015 to 2018: A nationwide record linkage study. PLoS Med. 2023 Feb 24;20(2):e1004181. doi: 10.1371/journal.pmed.1004181. PMID: 36827251; PMCID: PMC9956022.

Ximenes RAA, Miranda-Filho DB, Brickley EB, Barreto de Araújo TV, Montarroyos UR, Abtibol-Bernardino MR, Mussi-Pinhata MM, Duarte G, Coutinho CM, Biason de Moura Negrini SF, Costa Alecrim MDG, Albuquerque de Almeida Peixoto LF, Lopes Moreira ME, Zin A, Pereira Júnior JP, Nielsen-Saines K, Turchi Martelli CM, Rodrigues LC, de Souza WV, Ventura LO, de Oliveira CS, de Matos H, Furtado Serra EM, Souza Gomes LT, Nogueira ML, Estofolete C, Vaz-Oliani DC, Passos SD, Moron A, Duarte Rodrigues MM, Pereira Sarmento SG, Turchi MD, Pela Rosado LE, de Sene Amâncio Zara AL, Franco Gomes MB, Schuler-Faccini L, Herrero- Silva J, Amorim MM, Melo AO, Ledo Alves da Cunha AJ, Prata-Barbosa A, Amim J Jr, Rezende-Filho J, Calcagno JI, Júnior Alcântara LC, de Almeida BL, Hofer CB, Machado ES, de Siqueira IC, Martinez-Espinoza FE, Brasil P. Risk of adverse outcomes in offspring with RT-PCR confirmed prenatal Zika virus exposure: An individual participant data meta-analysis of 13 cohorts in the Zika Brazilian Cohorts Consortium. Lancet Reg Health Am. 2023 Jan;17:100395. doi: 10.1016/j.lana.2022.100395. Epub 2022 Nov 28. PMID: 36714276; PMCID: PMC9880800.

de Souza LCMR, Ribeiro CTM, Hamanaka T, Ribeiro LC, de Souza NCO, Pone SM, Nielsen-Saines K, Brickley EB, Moreira MEL, da Silva Pone MV. Characterizing Disabilities in Preschool Aged Children with Congenital Zika Virus Syndrome with the ICF Model. Viruses. 2022 Sep 23;14(10):2108. doi: 10.3390/v14102108. PMID: 36298663; PMCID: PMC9611262.

Paixão ES, Fernandes QHRF, Cardim LL, Pescarini JM, Costa MCN, Falcão IR, Brickley EB, Santos AC, Portela Souza A, Carvalho-Sauer RCO, Smeeth L, Rodrigues LC, Barreto ML, Teixeira MG. Socioeconomic risk markers of congenital Zika syndrome: a nationwide, registry-based study in Brazil. BMJ Glob Health. 2022 Sep;7(9):e009600. doi: 10.1136/bmjgh-2022-009600. PMID: 36175039; PMCID: PMC9528618.

da Hora LCD, Muniz LF, Venâncio LGA, Advíncula KP, da Silva JD, de Albuquerque Britto DBL, de Barros Miranda Filho D, Brickley EB, de Alencar Ximenes RA, da Silva Caldas Neto S, de Carvalho Leal M. Cortical Auditory Evoked Potentials in Children with Prenatal Exposure to Zika Virus. Viruses. 2022 Aug 30;14(9):1923. doi: 10.3390/v14091923. PMID: 36146729; PMCID: PMC9502411.

Ramos RCF, de Barros Miranda-Filho D, Martelli CMT, de Araújo TVB, Wanderley Rocha MA, van der Linden V, de Carvalho MDCG, Rodrigues LC, Montarroyos UR, de Souza WV, de Albuquerque MFPM, Brickley EB, de Alencar Ximenes RA. Characteristics of children of the Microcephaly Epidemic Research Group Pediatric Cohort who developed postnatal microcephaly. Sci Rep. 2022 Sep 22;12(1):15778. doi: 10.1038/s41598-022-19389-w. PMID: 36138062; PMCID: PMC9500100.

Pescarini JM, Rodrigues M, Paixão ES, Cardim L, Brito CAA, Costa MDCN, Santos AC, Smeeth L, Teixeira MDG, Souza APF, Barreto ML, Brickley EB. Dengue, Zika, and Chikungunya viral circulation and hospitalization rates in Brazil from 2014 to 2019: An ecological study. PLoS Negl Trop Dis. 2022 Jul 27;16(7):e0010602. doi: 10.1371/journal.pntd.0010602. PMID: 35895718; PMCID: PMC9359537.

de Vasconcelos RAL, Ximenes RAA, Calado AA, Martelli CMT, Veras Gonçalves A, Brickley EB, Araújo TVB, Wanderley Rocha MA, Miranda-Filho DB. Zika-Related Microcephaly and Its Repercussions for the Urinary Tract: Clinical, Urodynamic, Scintigraphic and Radiological Aspects. Viruses. 2022 Jul 11;14(7):1512. doi: 10.3390/v14071512. PMID: 35891492; PMCID: PMC9320115.

Paixao ES, Rodrigues LC, Costa MDCN, de Carvalho-Sauer RCO, Oliveira WK, Cardim LL, Schuler-Faccini L, Andrade RFS, Rodrigues MS, Brickley EB, Veiga RV, Costa LC, Carmo EH, Smeeth L, Barreto ML, Teixeira MG. Population-based surveillance for congenital zika virus syndrome: a latent class analysis of recorded cases from 2015-2018. BMC Pregnancy Childbirth. 2022 Jun 29;22(1):530. doi: 10.1186/s12884-022-04860-3. PMID: 35768806; PMCID: PMC9245223.

Hamanaka T, Ribeiro CTM, Pone S, Gomes SC, Nielsen-Saines K, Brickley EB, Moreira ME, Pone M. Longitudinal Follow-Up of Gross Motor Function in Children with Congenital Zika Virus Syndrome from a Cohort in Rio de Janeiro, Brazil. Viruses. 2022 May 28;14(6):1173. doi: 10.3390/v14061173. PMID: 35746646; PMCID: PMC9229488.

Rosado LEP, Aquino EC, Brickley EB, França DDDS, Silva FPA, Silva VLD, Lopes AF, Turchi MD. Socioeconomic disparities associated with symptomatic Zika virus infections in pregnancy and congenital microcephaly: A spatiotemporal analysis from Goiânia, Brazil (2016 to 2020). PLoS Negl Trop Dis. 2022 Jun 17;16(6):e0010457. doi: 10.1371/journal.pntd.0010457. PMID: 35714146; PMCID: PMC9246127.

Power GM, Vaughan AM, Qiao L, Sanchez Clemente N, Pescarini JM, Paixão ES, Lobkowicz L, Raja AI, Portela Souza A, Barreto ML, Brickley EB. Socioeconomic risk markers of arthropod-borne virus (arbovirus) infections: a systematic literature review and meta-analysis. BMJ Glob Health. 2022 Apr;7(4):e007735. doi: 10.1136/bmjgh-2021-007735. PMID: 35428678; PMCID: PMC9014035.

Lobkowicz L, Miranda-Filho DB, Montarroyos UR, Martelli CMT, Barreto de Araújo TV, De Souza WV, Bezerra LCA, Dhalia R, Marques ETA, Clemente NS, Webster J, Vaughan A, Webb EL, Brickley EB, Alencar Ximenes RA; Microcephaly Epidemic Research Group. Co-circulation of Chikungunya Virus during the 2015-2017 Zika Virus Outbreak in Pernambuco, Brazil: An Analysis of the Microcephaly Epidemic Research Group Pregnancy Cohort. Am J Trop Med Hyg. 2022 Apr 11;106(6):1711–20. doi: 10.4269/ajtmh.21-0449. Epub ahead of print. PMID: 35405646; PMCID: PMC9209936.

Wilder-Smith A, Brickley EB, Ximenes RAA, Miranda-Filho DB, Turchi Martelli CM, Solomon T, Jacobs BC, Pardo CA, Osorio L, Parra B, Lant S, Willison HJ, Leonhard S, Turtle L, Ferreira MLB, de Oliveira Franca RF, Lambrechts L, Neyts J, Kaptein S, Peeling R, Boeras D, Logan J, Dolk H, Orioli IM, Neumayr A, Lang T, Baker B, Massad E, Preet R. The legacy of ZikaPLAN: a transnational research consortium addressing Zika. Glob Health Action. 2021 Oct 26;14(sup1):2008139. doi: 10.1080/16549716.2021.2008139. PMID: 35377284; PMCID: PMC8986226.

Paixao ES, Cardim LL, Costa MCN, Brickley EB, de Carvalho-Sauer RCO, Carmo EH, Andrade RFS, Rodrigues MS, Veiga RV, Costa LC, Moore CA, França GVA, Smeeth L, Rodrigues LC, Barreto ML, Teixeira MG. Mortality from Congenital Zika Syndrome - Nationwide Cohort Study in Brazil. N Engl J Med. 2022 Feb 24;386(8):757-767. doi: 10.1056/NEJMoa2101195. PMID: 35196428; PMCID: PMC7612437.

Tiene SF, Cranston JS, Nielsen-Saines K, Kerin T, Fuller T, Vasconcelos Z, Marschik PB, Zhang D, Pone M, Pone S, Zin A, Brickley E, Orofino D, Brasil P, Adachi K, da Costa ACC, Lopes Moreira ME. Early Predictors of Poor Neurologic Outcomes in a Prospective Cohort of Infants With Antenatal Exposure to Zika Virus. Pediatr Infect Dis J. 2022 Mar 1;41(3):255-262. doi: 10.1097/INF.0000000000003379. PMID: 35144270; PMCID: PMC8901197.

Muniz LF, Maciel RJF, Ramos DS, Albuquerque KMG, Leão ÂC, Van Der Linden V, Paixão ES, Brickley EB, Cordeiro MT, Leitão GGS, Caldas SS, Leal MC. Audiological follow-up of children with congenital Zika syndrome. Heliyon. 2022 Jan 7;8(1):e08720. doi: 10.1016/j.heliyon.2022.e08720. PMID: 35059518; PMCID: PMC8760538.

Lobkowicz L, Power GM, De Souza WV, Montarroyos UR, Martelli CMT, de Araùjo TVB, Bezerra LCA, Dhalia R, Marques ETA, Miranda-Filho DB, Brickley EB, Ximenes RAA. Neighbourhood-level income and Zika virus infection during pregnancy in Recife, Pernambuco, Brazil: an ecological perspective, 2015-2017. BMJ Glob Health. 2021 Dec;6(12):e006811. doi: 10.1136/bmjgh-2021-006811. PMID: 34857522; PMCID: PMC8640636.

Ribeiro CTM, Hamanaka T, Pone S, Aibe MS, Gomes SC, Nielsen-Saines K, Brickley EB, Moreira ME, Pone M. Gross motor function in children with Congenital Zika Syndrome from Rio de Janeiro, Brazil. Eur J Pediatr. 2022 Feb;181(2):783-788. doi: 10.1007/s00431-021-04270-1. Epub 2021 Oct 1. PMID: 34596742; PMCID: PMC8821062.

Sobral da Silva PF, Eickmann SH, Ximenes RAA, Martelli CMT, Brickley EB, C Lima M, Montarroyos UR, Carvalho MDCG, Rodrigues LC, Araújo TVB, Ventura LO, da Silva Oliveira DM, Ferreira Ramos RC, Miranda-Filho DB, On Behalf Of The Microcephaly Epidemic Research Group Merg. Neurodevelopment in Children Exposed to Zika Virus: What Are the Consequences for Children Who Do Not Present with Microcephaly at Birth? Viruses. 2021 Jul 22;13(8):1427. doi: 10.3390/v13081427. PMID: 34452293; PMCID: PMC8402706.

Qiao L, Martelli CMT, Raja AI, Sanchez Clemente N, de Araùjo TVB, Ximenes RAA, Miranda-Filho DB, Ramond A, Brickley EB. Epidemic preparedness: Prenatal Zika virus screening during the next epidemic. BMJ Glob Health. 2021 Jun;6(6):e005332. doi: 10.1136/bmjgh-2021-005332. PMID: 34117012; PMCID: PMC8202108.

Alecrim MDGC, Amorim MMR, Araújo TVB, Brasil P, Brickley EB, Castilho MDC, Coelho BP, Cunha AJLAD, Duarte G, Estofolete CF, Gurgel RQ, Herrero-Silva J, Hofer CB, Lopes ASA, Martelli CMT, Melo ASO, Miranda-Filho DB, Montarroyos UR, Moreira ME, Mussi-Pinhata MM, Oliveira CS, Passos SD, Prata-Barbosa A, Santos DND, Schuler-Faccini L, Silva AAMD, Siqueira IC, Sousa PDS, Turchi MD, Ximenes RAA, Zara ALSA, Zika Brazilian Cohorts Consortium Zbc-Consortium. Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta- Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy. Viruses. 2021 Apr 16;13(4):687. doi: 10.3390/v13040687. PMID: 33923434; PMCID: PMC8072625.

de Barros Miranda-Filho D, Brickley EB, Ramond A, Martelli CMT, Sanchez Clemente N, Velho Barreto de Araújo T, Rodrigues LC, Montarroyos UR, de Souza WV, de Albuquerque MFPM, Ventura LO, Marques ETA, Leal MC, Eickmann SH, Wanderley Rocha MA, Sobral da Silva PF, Gomes Carvalho MDC, Ramos RCF, da Silva Oliveira DM, Xavier MDN, Vasconcelos RAL, Veras Gonçalves A, Brainer AM, Tenório Cordeiro M, Arraes de Alencar Ximenes R, On Behalf Of The Microcephaly Epidemic Research Group. The Microcephaly Epidemic Research Group Paediatric Cohort (MERG-PC): A Cohort Profile. Viruses. 2021 Apr 1;13(4):602. doi: 10.3390/v13040602. PMID: 33916084; PMCID: PMC8067191.

Andrade LM, Baker Meio MD, Gomes SC Jr, Souza JP, Figueiredo MR, Costa RP, Brasil P, Nielsen-Saines K, Brickley E, Moreira MEL. Language delay was associated with a smaller head circumference at birth in asymptomatic infants prenatally exposed to the Zika virus. Acta Paediatr. 2021 Aug;110(8):2375-2381. doi: 10.1111/apa.15878. Epub 2021 May 3. PMID: 33872416; PMCID: PMC8286322.

Ximenes RAA, Miranda-Filho DB, Montarroyos UR, Martelli CMT, Araújo TVB, Brickley E, Albuquerque MFPM, Souza WV, Ventura LO, Ventura CV, Gois AL, Leal MC, Oliveira DMDS, Eickmann SH, Carvalho MDCG, Silva PFSD, Rocha MAW, Ramos RCF, Brandão-Filho SP, Cordeiro MT, Bezerra LCA, Dimech G, Valongueiro S, Pires P, Castanha PMDS, Dhalia R, Marques-Júnior ETA, Rodrigues LC; Microcephaly Epidemic Research Group (MERG). Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil. PLoS Negl Trop Dis. 2021 Mar 8;15(3):e0009216. doi: 10.1371/journal.pntd.0009216. PMID: 33684110; PMCID: PMC7971861.

Leal MC, Seabra Ramos D, Pinto Bezerra T, Vilela AESC, Maciel RJF, Rodrigues M, Lira M, Cavalcanti KPS, Van der Linden V, Cordeiro MT, Miranda D, Ximenes R, Brickley EB, Caldas SS. The Prevalence of Adenoid Hypertrophy among Children with Zika Related Microcephaly. Viruses. 2021 Jan 5;13(1):62. doi: 10.3390/v13010062. PMID: 33466404; PMCID: PMC7824820.

Souza JP, Méio MDBB, de Andrade LM, Figueiredo MR, Gomes Junior SC, Pereira Junior JP, Brickley E, Lopes Moreira ME. Adverse fetal and neonatal outcomes in pregnancies with confirmed Zika Virus infection in Rio de Janeiro, Brazil: A cohort study. PLoS Negl Trop Dis. 2021 Jan 4;15(1):e0008893. doi: 10.1371/journal.pntd.0008893. PMID: 33395421; PMCID: PMC7781387.

Veras Gonçalves A, Miranda-Filho DB, Rocha Vilela LC, Ramos RCF, de Araújo TVB, de Vasconcelos RAL, Wanderley Rocha MA, Eickmann SH, Cordeiro MT, de Oliveira Ventura MLV, Montarroyos UR, Mertens Brainer A, Costa Gomes MD, da Silva PFS, Martelli CMT, Brickley EB, Ximenes RAA. Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil. Viruses. 2020 Dec 22;13(1):1. doi: 10.3390/v13010001. PMID: 33374895; PMCID: PMC7821916.

Ades AE, Brickley EB, Alexander N, Brown D, Jaenisch T, Miranda-Filho DB, Pohl M, Rosenberger KD, Soriano-Arandes A, Thorne C, Ximenes RAA, de Araújo TVB, Avelino-Silva VI, Bethencourt Castillo SE, Borja Aburto VH, Brasil P, Christie CDC, de Souza WV, Gotuzzo H JE, Hoen B, Koopmans M, Martelli CMT, Martins Teixeira M, Marques ETA, Miranda MC, Montarroyos UR, Moreira ME, Morris JG, Rockx B, Saba Villarroel PM, Soria Segarra C, Tami A, Turchi MD, Giaquinto C, de Lamballerie X, Wilder-Smith A; EC Zika Consortia Vertical Transmission Study Group. Zika virus infection in pregnancy: a protocol for the joint analysis of the prospective cohort studies of the ZIKAlliance, ZikaPLAN and ZIKAction consortia. BMJ Open. 2020 Dec 15;10(12):e035307. doi: 10.1136/bmjopen-2019-035307. PMID: 33323426; PMCID: PMC7745317.

Power GM, Francis SC, Sanchez Clemente N, Vasconcelos Z, Brasil P, Nielsen- Saines K, Brickley EB, Moreira ME. Examining the Association of Socioeconomic Position with Microcephaly and Delayed Childhood Neurodevelopment among Children with Prenatal Zika Virus Exposure. Viruses. 2020 Nov 23;12(11):1342. doi: 10.3390/v12111342. PMID: 33238584; PMCID: PMC7700457.

de Vasconcelos RAL, Ximenes RAA, Calado AA, Martelli CMT, Gonçalves AV, Brickley EB, de Araújo TVB, Rocha MAW, Miranda-Filho DB. Surgical findings in cryptorchidism in children with Zika-related microcephaly: a case series. BMC Urol. 2020 Nov 23;20(1):186. doi: 10.1186/s12894-020-00721-3. PMID: 33225931; PMCID: PMC7681962.

Sanchez Clemente N, Brickley EB, Furquim de Almeida M, Witkin SS, Duarte Passos S, Jundiai Zika Cohort Group T. Can Zika Virus Infection in High Risk Pregnant Women Be Differentiated on the Basis of Symptoms? Viruses. 2020 Nov 5;12(11):1263. doi: 10.3390/v12111263. PMID: 33167566; PMCID: PMC7694531.

Sobral da Silva PF, Eickmann SH, Arraes de Alencar Ximenes R, Ramos Montarroyos U, de Carvalho Lima M, Turchi Martelli CM, Velho Barreto de Araújo T, Brickley EB, Cunha Rodrigues L, Lima da Silva Pastich Gonçalves FC, Costa Gomes Carvalho MD, Vieira de Souza W, de Barros Miranda-Filho D. Pediatric neurodevelopment by prenatal Zika virus exposure: a cross-sectional study of the Microcephaly Epidemic Research Group Cohort. BMC Pediatr. 2020 Oct 10;20(1):472. doi: 10.1186/s12887-020-02331-2. PMID: 33038931; PMCID: PMC7547521.

Ramond A, Lobkowicz L, Clemente NS, Vaughan A, Turchi MD, Wilder-Smith A, Brickley EB. Postnatal symptomatic Zika virus infections in children and adolescents: A systematic review. PLoS Negl Trop Dis. 2020 Oct 2;14(10):e0008612. doi: 10.1371/journal.pntd.0008612. PMID: 33006989; PMCID: PMC7556487.

Oliveira DMDS, Miranda-Filho DB, Ximenes RAA, Montarroyos UR, Martelli CMT, Brickley EB, Gouveia MCL, Ramos RC, Rocha MÂW, Araujo TVB, Eickmann SH, Rodrigues LC, Bernardes JPOS, Pinto MHT, Soares KPND, Araújo CMT, Militão- Albuquerque MFP, Santos ACOD. Comparison of Oropharyngeal Dysphagia in Brazilian Children with Prenatal Exposure to Zika Virus, With and Without Microcephaly. Dysphagia. 2021 Aug;36(4):583-594. doi: 10.1007/s00455-020-10173-4. Epub 2020 Sep 4. PMID: 32886254; PMCID: PMC8289769.

Sanchez Clemente N, Brickley EB, Paixão ES, De Almeida MF, Gazeta RE, Vedovello D, Rodrigues LC, Witkin SS, Passos SD. Zika virus infection in pregnancy and adverse fetal outcomes in São Paulo State, Brazil: a prospective cohort study. Sci Rep. 2020 Jul 29;10(1):12673. doi: 10.1038/s41598-020-69235-0. PMID: 32728054; PMCID: PMC7391725.

Brasil P, Vasconcelos Z, Kerin T, Gabaglia CR, Ribeiro IP, Bonaldo MC, Damasceno L, Pone MV, Pone S, Zin A, Tsui I, Adachi K, Pereira JP Jr, Gaw SL, Carvalho L, Cunha DC, Guida L, Rocha M, Cherry JD, Wang L, Aliyari S, Cheng G, Foo SS, Chen W, Jung J, Brickley E, Moreira MEL, Nielsen-Saines K. Zika virus vertical transmission in children with confirmed antenatal exposure. Nat Commun. 2020 Jul 14;11(1):3510. doi: 10.1038/s41467-020-17331-0. PMID: 32665616; PMCID: PMC7360785.

Clemente NS, Ramond A, Turchi Martelli CM, Brickley EB. Geographies of risk: Emerging infectious diseases and travel health data. Travel Med Infect Dis. 2020 Jul-Aug;36:101806. doi: 10.1016/j.tmaid.2020.101806. Epub 2020 Jun 25. PMID: 32592905; PMCID: PMC7314681.

Lobkowicz L, Ramond A, Sanchez Clemente N, Ximenes RAA, Miranda-Filho DB, Montarroyos UR, Martelli CMT, de Araújo TVB, Brickley EB. The frequency and clinical presentation of Zika virus coinfections: a systematic review. BMJ Glob Health. 2020 May;5(5):e002350. doi: 10.1136/bmjgh-2020-002350. PMID: 32381652; PMCID: PMC7228501.

de Vasconcelos RAL, Ximenes RAA, Calado AA, Martelli CMT, Gonçalves AV, Brickley EB, de Araújo TVB, Wanderley Rocha MA, Miranda-Filho DB. Cryptorchidism in Children with Zika-Related Microcephaly. Am J Trop Med Hyg. 2020 May;102(5):982-984. doi: 10.4269/ajtmh.19-0753. PMID: 32157994; PMCID: PMC7204599.

Peçanha PM, Gomes Junior SC, Pone SM, Pone MVDS, Vasconcelos Z, Zin A, Vilibor RHH, Costa RP, Meio MDBB, Nielsen-Saines K, Brasil P, Brickley E, Lopes Moreira ME. Neurodevelopment of children exposed intra-uterus by Zika virus: A case series. PLoS One. 2020 Feb 28;15(2):e0229434. doi: 10.1371/journal.pone.0229434. PMID: 32109947; PMCID: PMC7048286.

Carvalho MDCG, Ximenes RAA, Montarroyos UR, da Silva PFS, Andrade-Valença LPA, Eickmann SH, Ramos RC, Rocha MÂW, de Araujo TVB, de Albuquerque MFPM, Martelli CMT, de Souza WV, Brickley EB, Miranda-Filho DB; Microcephaly Epidemic Research Group. Early epilepsy in children with Zika-related microcephaly in a cohort in Recife, Brazil: Characteristics, electroencephalographic findings, and treatment response. Epilepsia. 2020 Mar;61(3):509-518. doi: 10.1111/epi.16444. Epub 2020 Feb 17. PMID: 32065676; PMCID: PMC7155083.

Soares F, Abranches AD, Villela L, Lara S, Araújo D, Nehab S, Silva L, Amaral Y, Junior SCG, Pone S, Lobkowicz L, Clemente NS, Brasil P, Nielsen-Saines K, Pone M, Brickley E, Moreira ME. Zika virus infection in pregnancy and infant growth, body composition in the first three months of life: a cohort study. Sci Rep. 2019 Dec 16;9(1):19198. doi: 10.1038/s41598-019-55598-6. PMID: 31844129; PMCID: PMC6915782.

Sobhani NC, Avvad-Portari E, Nascimento ACM, Machado HN, Lobato DSS, Pereira JP, Esquivel MS, Vasconcelos ZC, Zin AA, Tsui I, Adachi K, Brickley EB, Fisher SJ, Nielsen-Saines K, Brasil P, Moreira ME, Gaw SL. Discordant Zika Virus Findings in Twin Pregnancies Complicated by Antenatal Zika Virus Exposure: A Prospective Cohort. J Infect Dis. 2020 May 11;221(11):1838-1845. doi: 10.1093/infdis/jiz629. PMID: 31773163; PMCID: PMC7213575.

Wilder-Smith A, Preet R, Brickley EB, Ximenes RAA, Miranda-Filho DB, Turchi Martelli CM, Araújo TVB, Montarroyos UR, Moreira ME, Turchi MD, Solomon T, Jacobs BC, Villamizar CP, Osorio L, de Filipps AMB, Neyts J, Kaptein S, Huits R, Ariën KK, Willison HJ, Edgar JM, Barnett SC, Peeling R, Boeras D, Guzman MG, de Silva AM, Falconar AK, Romero-Vivas C, Gaunt MW, Sette A, Weiskopf D, Lambrechts L, Dolk H, Morris JK, Orioli IM, O'Reilly KM, Yakob L, Rocklöv J, Soares C, Ferreira MLB, Franca RFO, Precioso AR, Logan J, Lang T, Jamieson N, Massad E. ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Glob Health Action. 2019;12(1):1666566. doi: 10.1080/16549716.2019.1666566. PMID: 31640505; PMCID: PMC6818126.

Ximenes RAA, Miranda-Filho DB, Brickley EB, Montarroyos UR, Martelli CMT, Araújo TVB, Rodrigues LC, de Albuquerque MFPM, de Souza WV, Castanha PMDS, França RFO, Dhália R, Marques ETA; Microcephaly Epidemic Research Group (MERG). Zika virus infection in pregnancy: Establishing a case definition for clinical research on pregnant women with rash in an active transmission setting. PLoS Negl Trop Dis. 2019 Oct 7;13(10):e0007763. doi: 10.1371/journal.pntd.0007763. PMID: 31589611; PMCID: PMC6797234.

Sanchez Clemente N, Rodrigues M, Pascalicchio AP, Gazeta RE, Vedovello D, Brickley EB, De Almeida MF, Passos SD. Cohort profile: the Jundiaí Zika cohort (JZC), a pregnancy and birth cohort in São Paulo state, Brazil. BMJ Open. 2019 Aug 26;9(8):e027947. doi: 10.1136/bmjopen-2018-027947. PMID: 31455701; PMCID: PMC6721643.

Wilder-Smith A, Wei Y, Araújo TVB, VanKerkhove M, Turchi Martelli CM, Turchi MD, Teixeira M, Tami A, Souza J, Sousa P, Soriano-Arandes A, Soria-Segarra C, Sanchez Clemente N, Rosenberger KD, Reveiz L, Prata-Barbosa A, Pomar L, Pelá Rosado LE, Perez F, Passos SD, Nogueira M, Noel TP, Moura da Silva A, Moreira ME, Morales I, Miranda Montoya MC, Miranda-Filho DB, Maxwell L, Macpherson CNL, Low N, Lan Z, LaBeaud AD, Koopmans M, Kim C, João E, Jaenisch T, Hofer CB, Gustafson P, Gérardin P, Ganz JS, Dias ACF, Elias V, Duarte G, Debray TPA, Cafferata ML, Buekens P, Broutet N, Brickley EB, Brasil P, Brant F, Bethencourt S, Benedetti A, Avelino-Silva VL, Ximenes RAA, Alves da Cunha A, Alger J; Zika Virus Individual Participant Data Consortium. Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children. BMJ Open. 2019 Jun 18;9(6):e026092. doi: 10.1136/bmjopen-2018-026092. PMID: 31217315; PMCID: PMC6588966.

Brickley EB, Rodrigues LC. Further pieces of evidence in the Zika virus and microcephaly puzzle. Lancet Child Adolesc Health. 2018 Mar;2(3):162-164. doi: 10.1016/S2352-4642(18)30021-X. Epub 2018 Jan 12. PMID: 30169250; PMCID: PMC6522374.